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CC You can still catch the NYC Opera's production of Jonathan Miller's 1920's version of MIKADO: Nov 4, 6, 8, & 22. Visit nycopera for details CC The MIT G&S Players' fall production, RUDDIGORE, will take place November 7, 8, 13 & 14 at 8pm and November 9 & 15 at 2pm. Producer: Erin Tyndall, Stage Director: Andrew Sweet, Vocal Director: Katherine Bryant, and Orchestra Director: Thomas Dawkins. Other NEGASSers involved: Rebecca Burstein, Skyler Wrench, and Allegta Martin. [THESPIS is in the works for Spring 2004! - the MITG&SP web site tells Us: "This version of THESPIS will consist of two existing Sullivan tunes, "Climbing Over Rocky Mountain" and "Little Maid of Arcadee." All other music has been specially composed for this show by Colin Johnson, and the MIT G&S Players are pleased to be presenting the world premiere of this new work."] For more info, e-mail savoyards-request mit , phone 617 ; 253-0190, or visit : web t gsp www . CC Valley Light Opera VLO ; 's fall 2003 show, PINAFORE featuring Elaine Crane as Josephine ; , will be held Nov. 7, 8, 9, and 15 at 8 and Nov 9 at 2 PM. Visit their web site at vlo pin03tix or phone producer Jacqueline Haney 413 ; 585-5769 for tix and info. CC The Connecticut G&S Society's GONDOLIERS, directed by Bob Cumming with full orchestra conducted by Dr. John Dreslin, will take place at Middletown, CT, th High School on November 7 & 8, and Nov 9 2 For info phone 1-800-866-1606 or 866-873-2832 or write to PO Box 2152, Middletown, CT 06457. CC Brad Conner, Artistic Director of American Classics, invites NEGASSers to Rodgers & Hart's PeggyAnn Nov. 8, & Nov. 9, 4 at the Pickman Concert Hall of the Longy School of Music, 27 Garden Street, Cambridge, MA. Yes, We know it's not! - but Brad tells Us this is a real G&S parody, and that the cast which is full of local G&S stars like Eric Bronner, Brad Conner, David Frieze, Bob Jolly, Mary Ann Lanier, Brent Reno, Ben Sears, Margaret Ulmer - regulars with groups like the and altace.
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NoticetoPurchaser This product is intended to be used for research purposes only. It is not to be used for drug or diagnostic purposes, nor is it intended for human use. Clontech products may not be resold, modified for resale, or used to manufacture commercial products without written approval of Clontech Laboratories, Inc. Allegra is a trademark of Beckman Coulter. Multifuge is a registered trademark of Heraeus. Clontech, Clontech logo and all other trademarks are the property of Clontech Laboratories, Inc. Clontech is a Takara Bio Company. 2005 Clontech Laboratories, Inc. clontech Protocol No. PT3783-1 Version No. PR4753.
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1. All growth figures are on a comparable basis versus 2004 pro forma 2. Based on a rate of $1.25 to 1 Euro 3. Non-GAAP financial measure; excludes the material impacts of purchase accounting treatment of the Aventis acquisition and certain acquisition-related integration and restructuring costs. Based on average number of shares of 1.3365 billion. 2005 Basic EPS equaled 1.69. 4. Excluding U.S. sales from 4 genericized products: Allegra from Sept. 05, Amaryl from Oct. 05, Arava from Sept.05 and DDAVP from July 05 IMS MIDAS all available channels - MAT Dec 2005 6. Dividend to be approved at Annual General Meeting of Shareholders, May 31, 2006.
LifeBrands a Publicis Healthcare Communications Group co. ; , New York. Vicki Mendelson, exec VP-mg dir; John Potenzano, VP & grp dir; Jackie Hill, assoc media dir. -- Ambien CR, BenzaClin, Lantus, Lovenox, Rimonabant, Taxotere, Uroxatral, Sculptra, Adacel, Daptacel, Menactra, Pentacel; Professional BrandsActonel, Allegra 30mg, Apidra, BenzaClin, Elitek, Eloxatin, Hyalgan, Ketek, Lantus, Lovenox, Multaq, Pact + , Rimonabant, Sculptra, Taxotere, Uroxatral, Xyzal, ActHIB, Adacel, Daptacel, Fluzone, Global Travel, Imovax, Menactra, Pentacel, Shared Pediactrics, TheraCys, Traveler's Vaccine, Tripedia. Medicus NY, New York. Diane Pencek, sr VP & grp acct dir; Scott Shevrin, sr VP & grp acct dir; Sherri Goldstein, sr VP & grp acct dir. -- Rimonabant, Multaq, Uroxatral, CNS Products. Torre Lazur McCann, Parsippany, N.J. Marci Piasecki, CEO. -- Plavix. Euro RSCG Worldwide, New York. Paul Klein, mg dir- Euro RSCG Tonic. -- cons awareness adv, Lantus, Lovenox, Apidra. Optimedia International U.S., New York. Vicki Mendelson, VP & mg dir. -- media svcs, DTC Brands - Ambien CR, BenzaClin, Lantus, Lovenox, Rimonabant, Taxotere, Uroxatral, Sculptra, Adacel, Daptacel, Menactra, Pentacel; Professional Brands Actonel, Allegra 30mg, Apidra, BenzaClin, Elitek, Eloxatin, Hyalgan, Lantus, Lovenox, Multaq, Pact + , Rimonabant, Sculptra, Taxotere, Uroxatral, Xyzal, ActHIB, Adacel, Daptacel, Fluzone, Global Travel, Imovax, Menactra, Pentacel, Shared Pediactrics, TheraCys, Traveler's Vaccine, Tripedia. Manning Selvage & Lee, New York. Stephanie Stamatakou, sr VP. -- pr, Allegra, Ambien.
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There is not an increase in the incidence of venous thromboembolism in patients receiving bevacizumab therapy 1-3 ; . However, if grade 3 venous thrombo-embolic event or incidentally discovered pulmonary embolus occurs, bevacizumab should be held for two weeks while anticoagulant treatment is initiated. Bevacizumab may be restarted if the patient is on a stable dose of anticoagulants. For pulmonary embolism grade 4 venous embolic event ; , bevacizumab should be stopped and anticoagulant therapy started. Bevacizumab may be resumed if the patient is stable and adequate anticoagulation achieved. If any life-threatening thromboembolism occurs, bevacizumab should be discontinued. B. Arterial thromboembolism An increase in incidence of arterial thromboembolism is observed in patients treated with bevacizumab compared with those receiving chemotherapy alone 4.5% vs. 2% ; . The mortality rate associated with this is 0.8% and 0.4%, respectively Table 6 ; . The arterial thromboembolic events include cerebrovascular accident, myocardial infarction, unstable angina, transient ischemic attack, claudication, subarachnoid hemorrhage and other arterial embolic events 2, 3 ; . Table 6. Incidence of arterial thromboembolism in cancer patients receiving bevacizumab therapy includes colorectal, breast, and non-small cell lung cancer patients ; Chemotherapy Chemotherapy with n 741 Bevacizumab n 1, 004 Arterial thromboembolism 15 2% ; 45 ; Mortality 3 0.4% ; 8 ; Retrospective review of clinical trials data indicate that patients over 65 years of age and those with a previous history of a arterial thromboembolic event are an increased risk for arterial thromboembolic event while on bevacizumab therapy. It is important to note that in the registration study 3 ; , a subgroup analysis of patients over 65 years showed a significant benefit from bevacizumab therapy and it should, therefore, be considered in this group, if appropriate. Of relevance, in an analysis of patients in three randomized clinical trials of bevacizumab, use of low dose aspirin 325 mg day ; was not associated with increased incidence of bleeding 12 ; . Prophylactic aspirin may be considered for those at high risk of thromboembolism provided there are no contra-indications to its usage. Recommendations A. Venous thromboembolism 1. Bevacizumab should be held for two weeks in patients with Grade 3 venous thromboembolic events or incidentally discovered pulmonary embolus. Bevacizumab may be resumed after initiation of therapeutic-dose anticoagulant therapy provided the patient is stable and no hemorrhagic complication is present. 2. In the event of a pulmonary embolus, bevacizumab should be stopped and anticoagulant therapy initiated. If the patient is stable and adequate anticoagulation is achieved, bevacizumab may be restarted. 3. Bevacizumab should be discontinued if any life-threatening venous thromboembolic event occurs. B. Arterial thromboembolism 1. Caution should be taken when starting bevacizumab in patients with a previous history of arterial thromboembolic events or those over 65 years of age. 2. Patients with a recent arterial thromboembolic event myocardial infarction, TIA, cerebrovascular accident or other event ; should not be treated with bevacizumab for at least six months, and bevacizumab should be started only if they are stable and asymptomatic. However, chemotherapy can be initiated before this. 3. Aspirin 325 mg day ; could be considered for suitable patients at high risk of arterial thromboembolic events. BC Cancer Agency Cancer Management Guidelines 5 10 Management Guidelines of Bevacizumab-Related Side Effects Developed: August 2006 Revised: 1 December 2006.
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