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This work was supported by National Institutes of Health Grant GM 54412 to M. E. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. To whom correspondence should be addressed: Dept. of Medicine, Medical College of Georgia, Augusta, GA 30912. Tel: 706-721-7652; Fax: 706-721-6608; E-mail: mganapat mail g . 1 The abbreviations used are: OCTN, novel organic cation transporter; TEA, tetraethylammonium; PEPT, peptide transporter; HPCT, human proximal convoluted tubule; HPLC, high pressure liquid chromatography; Mes, 4-morpholineethanesulfonic acid.

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