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The other associated risks involved with taking celebrex are an increased risk of heart attacks, strokes, skin reactions, stomach and intestinal problems, which are potentially deadly side effects.
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64.37 in 2001. This reflects the fact that doctors are prescribing more of the more expensive antiarthritics such as Celsbrex and Vioxx. These drugs represented 57% of the antiarthritic drug sales in 2001. National Institute for Health Care Management, "Prescription Drug Expenditures in 2001: Another Year of Escalating Costs, " April 2002 ; Price increases of individual drugs: This accounted for 37% of the overall spending boom. For example, the prices of some drugs rose substantially in 2001: Accutane 22.7% ; , Oxycontin 15.4% ; , Glucophage 14.4% ; , and Allegra 10.9% ; . National Institute for Health Care Management, "Prescription Drug Expenditures in 2001: Another Year of Escalating Costs, " April 2002 ; A small group of popular drugs are driving the spending increase: 34 drugs out of 9, 482 on the market ; accounted for 50.7% of the overall increase in national drug spending last year. National Institute for Health Care Management, "Prescription Drug Expenditures in 2001: Another Year of Escalating Costs, " April 2002 ; Lipitor, a drug used to treat high cholesterol, was the top-selling drug in 2001 with $4.5 billion in retail sales representing 3.7% of the total increase in consumer spending on prescription drugs. National Institute for Health Care Management, "Prescription Drug Expenditures in 2001: Another Year of Escalating Costs, " April 2002 ; Two antiarthitis drugs alone Vioxx and Celebeex accounted for 9.2% of the entire increase in prescription drug sales in the year 2000. National Institute for Health Care Management, "Prescription Drug Expenditures in 2000, " May 2001 ; Although Vioxx and Celebeex totaled $3.5 billion in sales in 2000, they do not represent significant improvements over older drugs. They are not more effective than ibuprofen at reducing pain and inflammation, and only slightly less likely to cause ulcers. U.S. Food and Drug Administration, "The Pink Sheet: The News This Week, " February 19, 2001.
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The third-annual Hockey for Heart, a grudge match for a great cause, takes place Tuesday, March 29 at 7 the Jock Harty Arena. Queen's Medicine Class of 2008 will square off against professors in a benefit hockey game to support Heart and Stroke Foundation of Ontario. Admission is $5 and features door prizes.
147; celebrex has been on the market just as long, and we haven t yet seen any signal of cardiac risk, says dr and celexa.
The utility scores for death and perfect health were set at 0.0 and 1.0 respectively. Appendix 4 Table 6 shows the absolute short-term utility decrement of 0.14 due to advers e events experienced during AVT65 and the absolute short-term utility increment of 0.04 for patients with SVR assumed to be of one-year duration in the base case ; . Additional details relating to the derivation of the utility scores appear in Appendix 4 Table 6.
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In this way health action is built on the existing, legal, administrative structures to avoid the creation of unsustainable parallel systems and processes. The governing structures are established around the local health facilities within them, so that each structure is responsible for a geographically discrete unit for service delivery. 4.4.2 Responsibilities of the linkage governing structures.
Before a crisis erupts, advance directives reverse the cycle of "learned helplessness" which has long plagued institutionalized mental health care. The competent execution of a legally-enforceable advance directive should be an option available to every individual in the State of Vermont--including, and perhaps especially, to those individuals with a psychiatric disability and cipro.
Both bextra and celebrex remain on the market, used largely by arthritis sufferers.
| Celebrex bextra vioxxThe dissent emphasized that the Court's ruling will "allow criminal defendants in petitioner's position to engage in opportunistic behavior .[and] hold up the trial for months by claiming that review after final judgment `would come too late' to prevent violation" of his rights Ref. 12, at 2190 ; . Justice Scalia also pointed out that these appeals would, if the majority's ruling is applied faithfully, include appeals from any trial court order that allegedly causes an infringement on constitutional rights, not only those orders having to do with medication. Discussion While the Supreme Court has answered some questions with respect to involuntary medication to restore CST, it has created others. First, the Court agreed with the Sixth Circuit's decision in Brandon, making it clear that a judicial hearing is necessary before a defendant can be forcibly medicated to restore CST. Although not explicitly addressed, the Court refers to "court" findings throughout its discussion of the Sell standard. In contrast, the Harper Court held that a judicial decision-maker was not required to medicate a dangerous prisoner involuntarily and that a panel of mental health professionals would suffice. This heightened requirement is probably related to the Sixth Amendment rights of pretrial detainees that are at stake in the CST context, but not in the Harper context, which involved convicted prisoners. The Supreme Court emphasized that alternative grounds for involuntary medication should be pursued before even addressing forced medication to restore competency. These grounds include capacity to consent to medication and dangerousness. With respect to the capacity to consent to medication, this inquiry is well defined. It is an analysis of the individual's ability to understand and appreciate the indications for; the risks, benefits, and side effects of; and the alternatives to the medication. As the majority opinion points out, all states have procedures to deal with this issue. Although the informed consent inquiry is well defined and states have clear procedures and rules in place, the dangerousness inquiry is more problematic. First, predicting violence, even in the short term, remains an inexact science. Even if the prediction could be made with an acceptable degree of accuracy, it is unclear what risk would constitute "dan88 and claritin.
There is hardly any tradition within child and adolescent psychopharmacology to participate in clinical trials. - Jan Buitelaar reports on the concensus meeting in March 2000.
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ROBIN MEADE, ACCENTHEALTH CO-HOST: HELLO, I'M ROBIN MEADE. DR. SANJAY GUPTA, ACCENTHEALTH CO-HOST: AND I'M DR. SANJAY GUPTA. YOU'RE WATCHING ACCENTHEALTH. THANKS FOR JOINING US. YOU KNOW, PEOPLE OFTEN TALK ABOUT THE HORMONAL CHANGES THAT WOMEN EXPERIENCE AS THEY AGE. MEADE: SPEAK FOR YOURSELF. LAUGHS ; GUPTA: ROBIN IS YOUNG. PUT THAT IN THERE. MEADE: I'M JUST TEASING. I KNOW WHAT YOU'RE TALKING ABOUT, THOUGH. THE PHYSICAL AND THE EMOTIONAL CHANGES THAT COME ALONG WITH AGING. GUPTA: THAT'S RIGHT, BUT HERE'S SOMETHING THAT'S VERY INTERESTING. CHANGES IN HORMONE LEVELS, AS WELL. MEADE: YOU DON'T SAY, MOODY. LAUGHS ; MEN CAN EXPERIENCE and climara.
| Oseltamivir is indicated for the prophylaxis of influenza in adults and children aged 13 years and older. Oseltamivir administered once daily has been shown to be effective both in seasonal prophylaxis among healthy persons and in post-exposure prophylaxis within families. In seasonal prophylaxis, the duration of medication has been up to 6 weeks, and in the post-exposure prophylaxis it has been 7-10 days. In seasonal prophylaxis among healthy adults, the protective efficacy of oseltamivir against laboratory-confirmed influenza was 74%, and against culture-proven influenza 87%. Even higher protection was observed in a study of 6-week seasonal prophylaxis among frail elderly subjects in residential home care setting; the protective efficacy against laboratory-confirmed influenza was 92%. In addition, the protective efficacy among elderly persons who had been vaccinated against influenza was 91%. In post-exposure prophylaxis in the family setting, the overall protective efficacy of oseltamivir among the contacts aged 12 years ; of an influenza-positive index case was 89%. In another postexposure prophylaxis study that included also children aged 1 year or older, the protective efficacy was 68%. Impact on the non-clinical infections, infectivity and immunogenicity An important feature of oseltamivir prophylaxis is that it does not prevent influenza infection per se, but works by preventing further transmission of newly formed viruses into adjacent cells. Therefore, oseltamivir prophylaxis does not suppress the antibody response to influenza infection if a subject acquires influenza during the prophylactic period. Experience on pandemic use use for avian influenza There are no data on the use of oseltamivir prophylaxis in a real pandemic situation. There are no properly controlled clinical studies in humans with respect to the current avian influenza strains. The prophylactic efficacy of oseltamivir was tested recently against a 2004 clinical isolate of the current avian influenza strain in a mouse model of influenza and significantly reduced the mortality against a lethal challenge of the virus at a dosage equivalent to the approved human dose., Survival was increased further with a prolonged treatment regimen. During the 2003 avian influenza H7N7 outbreak in the Netherlands, oseltamivir prophylaxis with the recommended dose of 75 mg once daily seemed to be effective to protect poultry workers and their close contacts. Sensitivity of different influenza strains Nine different types of influenza neuraminidases N1-N9 ; are currently known to exist. With few exceptions, only influenza viruses with N1 and N2 have circulated among humans during the past century. In addition to documented efficacy against strains with N1 or N2, oseltamivir has been shown to be potent in vitro against influenza virus neuraminidases N3-N9. Three distinct influenza pandemics occurred in the 20th century. The most devastating of them was the pandemic of 1918-20. This pandemic was caused by an H1N1 influenza virus. Oseltamivir has been shown to effectively inhibit recombinant influenza viruses possessing the haemagglutinin and neuraminidase of the 1918 strains of influenza both in vitro and in vivo in mice. The other pandemic, for instance, ionamin.
YOU HAVE TO MARKET your compounding practice if you want to succeed. One way to accomplish this is the office call. If you are not a marketer, this may be daunting. I offer these tips for the compounder who needs to market 1 ; Wear the white lab coat. It can be disconcerting to put it on in public. Have a badge that identifies you as a pharmacist with your name. The magic of the lab jacket is respect from the office staff. They will treat you differently. It is a simple way to create a good impression. All of a sudden you are on the same team. You do not have to prove yourself, show credentials, or try to impress. 2 ; Try to relax. It is not what you know but who you know. The way you say "hi" can make or break your visit. The more relaxed you are the better able you are to respond to the nuances of interpersonal communications. They know nothing about compounding. The doctor may be nervous because he may look nave. Everybody including your great aunt can give drug advice, but compounding advice, it is all voodoo science to them. Do not rehearse in the waiting room or quiz yourself with if they ask about this I will respond with that. Listen and be in the moment. If your are flat and at low energy, stay that way you are not a salesperson. Be yourself and let the conversation flow. 3 ; Have a prop. Bring something along that may interest the doctor. This way you have a frame of reference with which to initiate the conversation and all the memorization can be left at home. Bring something you have made or maybe a novel dispensing device and clonazepam.
NM ; Table ; . inhibited fMLP-stimulated, because rofecoxib.
Several stock analysts who follow drug companies said physicians will switch patients to celebrex in the short term and clonidine.
Case reports Case 1 A 58-year old woman received celecoxib Celrbrex ; for 2 years to treat fibromyalgia. Pathological liver enzyme levels were discovered incidentally. Abdominal sonography showed no cholelithiasis, the bile ducts were normal, and there were no signs of chronic liver disease. At admission the patient was icteric and physical examination revealed no signs of chronic liver disease. Her history confirmed that she was taking celecoxib more or less regularly but no other medication within the last three months. She tested negative for anti-HAV, anti-HCV, HBs-antigen, antimitochondrial antibody and antinuclear antibodies. Laboratory tests showed upper limit of normal ; : bilirubin 151 20 ; umol L, ASAT 1032 37 ; U L, ALAT 1058 40 ; U L, alka.
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Personal problems affecting an employee's performance, health or safety can often be overcome with proper education, counseling or treatment. CN is committed to helping any employee who may have a problem related to alcohol or any other drug. However, the employee must be willing to address the problem before it has any impact on performance. Seeking assistance is the preferred method of dealing with these problems. In these cases, the employee's employment or advancement opportunities will not be affected, provided approved rehabilitation is undertaken and results in satisfactory control of the problem. Employees should encourage co-workers who may have a current or emerging alcohol or drug problem to contact the Employee and Family Assistance Program EFAP ; , where assistance will be provided in line with the company's EFAP policy. Using the services provided by the EFAP does not eliminate the requirement to meet performance expectations. In addition to the educational program outlined in the EFAP policy, CN provides educational and awareness programs for employees concerning this policy and its application and coumadin and celebrex, for example, xanax.
Patients tolerating the therapy can expect a 75% reduction in PASI in 4 months. However, all studies of the mixture of esters have a high dropout rate due to gastrointestinal complaints diarrhoea, stomach cramps and tenesmus that occur in up to 60% of patients and flushing in 30% of patients, which is worse at the onset of therapy. Headaches may be associated with sudden flushing. The frequency of flushing is greatest at the onset of therapy and decreases with prolonged treatment time. Both adverse events lead to drug withdrawal in about 7% of patients.
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T's been a busy week for COX-2 inhibitors. At a media conference on Tuesday I heard how celecoxib Ceoebrex ; had been unfairly tarred with the same brush as rofecoxib Vioxx ; when it comes to cardiovascular risk. At the Pfizer press briefing, an impressive array of cardiologists, rheumatologists and even the editor of the EBM journal Bandolier said that there was no excess cardiac risk with normal doses of celecoxib. They were at.
On the other hand, some studies have suggested that the anti-inflammatory effects, at least in celebrex and meloxicam movicox ; may have beneficial effects on blood vessels, which would be heart protective.
An associate professor in the Department of o one thinks much about Gastrointestinal the wonders of aspirin, that Medicine and Nutriinnocuous and bitter tasting tion. "The only thing little white pill. Did you that gives me any know, for example, that it journeyed reservation about to the moon in 1969, or that it was recommending that actually prescribed 2, 400 years ago by everyone at increased Hippocrates? He found that chewing risk for colorectal on the bark of the willow tree, which cancer take low-dose contains the natural form of aspirin, aspirin is the somewhat unprerelieved aches and fevers. Most impresdictable side effects, gastrointestinal sive is that, in addition to combating bleeding and ulcers." arthritis and cardiovascular disease, In recent years, scientists have aspirin may even have the power to developed so-called "super aspirins, " prevent certain forms of cancer. the cyclooxygenase-2 COX-2 ; inhibiAspirin may not be the only tors such as celecoxib Celebrex ; . Often common drug to have this unexpected used in treating arthritis, the newer and beneficial side effect; several other non-steroidal anti-inflammatory drugs arthritis drugs, as well as some cholesare just as effective as aspirin at relievterol drugs, have also been associated ing pain but have fewer side effects. with a reduced incidence of cancer Aspirin's side effects are a result of its among long-term users in multiple nonspecific blocking action against two retrospective studies. As part of the cyclooxygenase enzymes, COX-1, which ongoing search for less toxic and less is needed for healthy mucosal tissues, expensive cancer therapies, researchers and COX-2, which is produced during at M. D. Anderson Cancer Center are inflammation and by precancerous investigating noncancer pharmaceuticals tissues. Celecoxib blocks only COX-2, for their chemoprevention and cancer the one implicated in cancer risk. treatment potential. See "Are COX-2 Inhibitors Safe?" on page 5 ; . Chemoprevention with NSAIDs According to Banu Arun, M.D., The old saying "Take two aspirin and an assistant professor in the Department call me in the morning" is now more or of Breast Medical Oncology, who is less being applied to patients at increased studying the use of celecoxib in breast risk for colorectal cancer. Long-term cancer prevention, COX-2 inhibitors daily aspirin use has been shown to cut have antiproliferative, apoptosiscolon polyp formation by as much as increasing, and antiangiogenic effects. 35%, so many physicians are now In her study, Dr. Arun wants to prescribing low-dose aspirin to patients determine whether celecoxib might at high risk for colorectal cancer. "There provide protection for women at is a huge body of epidemiologic data in increased risk of breast cancer who support of aspirin, and aspirin is cheap cannot take tamoxifen, the only as dirt, " said Patrick Lynch, M.D., J.D., preventive agent approved by Katie Prout Matias for this disease. Tamoxifen does not work in women with estrogen receptornegative breast cancer, which is typically more aggressive and deadly than estrogen receptorpositive breast cancer. "In early studies, it was shown that COX-2 inhibitors prevent both of these types of breast cancer, " said Dr. Arun. "In our current prospective study, the patients are given the drug either for six or 12 months, and then we look at tissue endpoints. We are looking at markers in the breast associated with risk and evaluating the reversal of these markers. If we can show reversal of these markers, then that agent can be taken to the next step." The markers they are looking at include cellular atypia, proliferation index, p53, HER2 neu, and apoptosis. Celecoxib has shown potential for use in preventing other types of cancer as well, including bladder, esophageal, skin, brain, lung, and head and neck cancer. The strongest evidence to date is in colorectal cancer prevention: In a study published in the New England Journal of Medicine in 2000, Dr. Lynch and others found that celecoxib reduced the number of polyps in patients with familial adenomatous polyposis FAP ; , a hereditary disease that leads to the formation of hundreds to thousands of colon polyps and a 100% colorectal cancer rate by age 40 or 50. As a result of that study, the Food and Drug Administration approved celecoxib in 1999 as adjunct therapy for patients with FAP. More recently, Dr. Lynch completed a phase I study of celecoxib in children and celexa.
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Drug Administration "FDA" ; representing approximately $500 million in total market size. In addition, the Company has 23 projects currently under development addressing a total market of approximately $2.9 billion. Selling, general and administrative expenses "SG&A" ; increased to $2.4 million for the first quarter of 2003 versus $1.5 million for the first quarter of 2002. SG&A accounted for 16.1% of net sales for the first quarter of 2003 compared with 16.6% of net sales for the first quarter of 2002. The dollar increase was primarily attributable to the Company's higher administrative expenses incurred to support Company growth. Operating income for the quarter was $2.0 million, or 13.4% of net sales, versus $1.7 million, or 18.5% of net sales, for the first quarter of 2002. This percentage decrease was primarily attributable to increased R&D activities and pre product launch expenses. Net income applicable to common stockholders for the first quarter of 2003 was $1.0 million, or $0.06 per diluted share, compared with the first quarter of 2002 net income applicable to common stockholders of $1.6 million, or $0.10 per diluted share. The decrease in net income is attributable to the Company recognizing a provision for income taxes of $711, 000, or $0.04 per diluted share, for the first quarter of 2003. The Company now reflects its net income after a provision for income taxes predominantly non-cash taxes ; as it recognized its deferred tax assets during the fourth quarter of 2002. Before provision for income taxes, the Company earned $1.8 million for the first quarter of 2003, a 5.4% increase, versus first quarter of 2002 net income of $1.7 million. 36. On May 14, 2003, Able filed its quarterly report with the SEC on Form 10-Q. The.
If you or a member of your family has suffered one of these serious cardiac events while taking vioxx or celebrex, we at leblanc & waddell stand ready to advise you as to your legal rights.
The withdrawal of Vioxx and a November 1, 2004, Wall Street Journal article which alleged that Merck officials knew about problems with Vioxx for several years. In the wake of Merck's withdrawal of Vioxx, plaintiffs' lawyers began to watch Pfizer closely because it sold and marketed the other two Cox-2 inhibitors approved by the FDA, Bextra and Celebrex. In December 2004, the plaintiffs' bar continued their assault on the largest pharmaceutical companies by bringing a securities fraud suit against Pfizer in the Southern District of New York. As in the Vioxx suit, the plaintiffs allege generally that Pfizer misrepresented the safety profile of Bextra and Celebrex. The major difference, however, is that although Bextra sales were suspended in 2005, Pfizer had not withdrawn the drugs from the market at the time the plaintiffs brought the suit. In their complaint, the plaintiffs point to various press articles from October and November 2004 questioning Pfizer's representations concerning the safety of the drugs. The event that led the plaintiffs to bring suit was not the withdrawal of the drug but rather when the FDA required that a cardiovascular safety warning be added to the Bextra label. In comparison to the 26% stock price drop when Vioxx was withdrawn, Pfizer's stock price dropped 0.47% upon this news in December 2004. It is telling that the plaintiffs brought suit even though Pfizer had not withdrawn either Bextra or Celebrex from the market, either voluntarily or at the direction of the FDA. Clearly, large pharmaceutical companies are being carefully targeted by the plaintiffs' bar. Indeed, in 2005, such major companies as AstraZeneca and GlaxoSmithKline have been sued for securities fraud. A significant decision on the duty to disclose adverse event reports A 2004 decision by the U.S. District Court for the Southern District of New York Judge William H. Pauley ; raises significant issues for all life sciences companies, and for their executives, because it tightens the relationship between adverse event reports and the duty under the federal securities laws to disclose information and update previous public statements. In In Bayer AG Securities Litigation, 2004 WL 2190357 S.D.N.Y. 2004 ; , plaintiffs filed suit against Bayer after its stock price dropped by 17% following Bayer's withdrawal of the cholesterol-lowering drug Baycol from the market in August 2001. The plaintiffs alleged that Bayer and certain of its officers made material misstatements and omissions in violation of Section 10 b ; of the Securities Exchange Act and Rule 10b5 promulgated thereunder. In particular, the plaintiffs contended that Bayer's prewithdrawal statements regarding Baycol's safety and profitability were rendered materially inaccurate by Bayer's failure to disclose adequate information about the drug's health risks that it received through numerous adverse event reports. Plaintiffs alleged that there was a meeting of Bayer's Global Drug Safety executives in August 2000, approximately one year before Baycol was withdrawn, to address growing concerns about the drug's safety. According to the plaintiffs, from this.
| Celebrex 100mg dailyPatients with a history of stomach ulcers or gastrointestinal bleeding are also at a greater risk of experienced celebrex bleeding.
That study aimed to test both aleve and celebrex as preventatives for alzheimer's disease.
Dorzolamide Trusopt ; Eye drops 2% . 9.31 5ml ; Twice daily in combination therapy Three time daily as monotherapy Acetazolamide Tablets 250mg four times a day .12.68 S R capsules 250mg twice daily .23.10 Injection 500mg .14.76 Notes 1. Carbonic anhydrase inhibitors are sulphonamide related drugs and may give rise to associated side effects especially with systemic treatment, e.g. blood disorders. 2. Acetazolamide is generally used as parenteral or occasionally oral therapy for acute glaucoma. Its side effects include paraesthesia, general malaise fatigue, dizziness, electrolyte imbalance and depression. 3. Dorzolamide is a useful second line agent. Dual therapy is more beneficial than mono therapy. Systemic side effects are less compared to oral iv acetazolamide.
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Does this product have documented proof to be as effective as its competitor for the same indications? No Yes If the answer is NO, consider the competition! If the answer is YES, move on. Is the product dosed fewer times a day than the competitive drug? No - 0 Yes - 10 Is the drug available in as many forms as the competitor? E.g. Susp., Tablet, Cream, Injection etc No - 0 Yes - 10 Is the supplier of this drug more likely to have adequate supplies at all times, compared to the supplier of the competing drug? No - 0 Yes - 10 Is the use of this drug more likely to keep patients out of the hospital, or provide early discharge, than the competing drug? No - 0 Yes - 10 This drug requires no special storage and good expiry dates compared to its competitor. No - 0 Yes - 10 Is the complete cost of therapy of this drug less than the comparable drug. No - 0 Yes - 10 Is there a proven lower risk of contraindications, warnings, precautions and side effects compared to the comparable drug? No- 0 Yes - 10 Does this drug require none or less costly monitoring than the competitor? e.g. Blood test etc. No - 0 Yes - 10 Does the manufacturer distributor provide financial support, eg. hospital equipment maintenance, educational seminars sponsorships, sampling, literature, sensitivity discs for antibiotics etc. totaling more than the savings on the use of the competitive drug? No - 0 Yes - 10 Page 78 TOTAL.
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Cetrorelix acetate Cetrotide Serono ; vials containing 250 microgram or 3 mg as powder for reconstitution Approved indication: assisted reproduction Australian Medicines Handbook Section 10.6.3 Luteinising hormone has an important role in the menstrual cycle. In assisted reproduction programs a premature surge in luteinising hormone can cause ovulation, and therefore disrupt the collection of oocytes. This surge can be prevented by antagonising luteinising hormone releasing hormone LHRH ; . Cetrorelix competes with LHRH for binding sites in the.
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2 Ethicals used in the treatment of metabolic and cardiovascular diseases, generics and consumer health care products are the core of our pharmaceuticals business. Sales in the Pharmaceuticals business sector rose by 2.0% to EUR 2, 914 million. The Ethicals division recorded 13% sales growth. Our investments in research and development rose by 10% to EUR 453 million; in Ethicals we invested EUR 379 million or 21% of this division's sales. The operating result amounted to EUR 453 million. The return on sales was 15.5%. The Pharmaceuticals business sector contributed 43% of the Merck Group's total sales, the share of the operating result was 61.
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