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Finding of vessel and nerve. In changing power group, Hsp 70 was induced greater after TTT of 100mW, 120mW and 140mW than control eyes. In changing exposure duration group, Hsp70 was induced normally but increased progressively after increasing exposure duration. Confocal scanning laser ophthalmoscopy and SEM revealed morphologic change of optic disc at the power of 140 mW or above. Increasing the exposure duration above 1minute 2, 3, and 5 minutes ; induced photocoagulation of the optic nerve tissue. Conclusion : Transpupillary laser irradiation of 100 mW power with 60 seconds induces an induction of Hsp70 in the optic nerve tissue without tissue damage. The induction of Hsp70 by TTT can be a possible candidate of future neuroprotective therapy in glaucoma. References : 1. Park KH, Cozier F, Ong OC, Caprioli J. Induction of heat shock protein 72 protects retinal ganglion cells in a rat glaucoma model. Invest Ophthalmol Vis Sci 2001; 42: 15221530. Reichel E, Berrocal AM, Ip M, Kroll AJ, Desai V, Duker JS, Puliafito CA. Transpupillary thermotherapy of occult subfoveal choroidal neovascularization in patients with age related macular degeneration. Ophthalmology 1999; 106: 19081914. Desmettre T, Maurage CA, Mordon S. Transpupillary Thermotherapy TTT ; With Short Duration Laser Exposures Induce Heat Shock Protein HSP ; Hyperexpression on Choroidoretinal Layers. Laser in Surgery and Medicine 2003; 33: 102107. Robertson DM, Salomao DR. The effect of transpupillary thermotherapy on the human macula. Arch Ophthalmol 2002; 120: 652656. Desmettre T, Maurage CA, Mordon S. Heat shock protein hyperexpression on chorioretinal layers after transpupillary thermotherapy. Invest Ophthalmol Vis Sci 2001; 42: 29762980. P239 NEUROPROTECTIVE EFFECTS OF BAX-INHIBITING PEPTIDES ON HYPOXIC DAMAGES IN PURIFIED CULTURED RETINAL GANGLION CELLS Y.-N. Chen1, M. Aihara1, M. Araie1, S. Matsuyama2 1 University of Tokyo, Tokyo, Japan, 2Case Western Reserve University, Cleveland, OH, United States of America.
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Specific areas of need, evident through the workshop discussions, were translated into the following draft recommendations: 1. For countries without filariasis, surveillance in selected sites and selected populations e.g. blood donors, military recruits ; should be carried out to detect isolated foci of transmission and or introduced cases. 2. In order to improve and or maintain high levels of compliance with MDA, countries should conduct practical and appropriate social research to better understand social issues related to filariasis elimination activities. This social research should lead to the design of specific messages and campaigns to change the identified behaviours. 3. Social mobilization activities should be multifaceted, targeting different media press, radio, television, etc ; and components of the society politicians, NGDO, religious groups, civil society, the private sector, etc ; with good interlinking between the various activities. Timing and penetration of each activity should also be monitored and evaluated. 4. The PacELF date collection and reporting system should be adopted and implemented by all member countries in order to ensure comparability and standardisation throughout the region in order to meet both the needs of member countries and of PacELF. Necessary training materials should be prepared and distributed as soon as possible. 5. The exclusion criteria of MDA as specified in the WHO guidelines for GELF should be strictly adhered to and implemented to achieve maximum coverage including lactating mothers and healthy elderly people. The criteria are as follows: a. Sick individuals who are unable to take medication ; b. Children less than 2 years of age c. Pregnant women 6. The recommendation made at last year's PacELF meeting for having available 100 mg and 300 mg DEC tablets should be aggressively pursued. Countries should indicate the size of tablets they require when placing orders. 7. Countries should develop a Healthy Islands approach that integrates filariasis elimination, helminth control, environmental health, and nutrition especially for Health Promoting Schools and communities. Technical capacity for the development of Healthy Islands approaches should be enhanced at regional level, buy the provision of guidelines and manuals, opportunities for networking, and training based. PacELF 2001 Annual Meeting Report 16.
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