We found no significant differences in clinical outcomes of AOE Table 7 ; for antiseptic vs antimicrobial, quinolone antibiotic vs nonquinolone antibiotic s ; , or steroid-antimicrobial vs antimicrobial alone. Regardless of topical agent used, about 65% to 90% of patients had clinical resolution within 7 to 10 days. One potential explanation is that differences among agents may have been missed because of low statistical power; however, all analyses had a combined sample size above 300 patients, making low power unlikely. Further, the magnitude of differences observed between treatments is very modest, with a maximum rate difference of 0.11 NNT of 9 patients ; . Therefore, even if additional studies were performed to increase power, it is likely that differences among treatments remain small or negligible. The only clinical comparison that achieved statistical significance in Table 7 is for steroid antibiotic vs steroid alone comparison 13 ; . The reason for inferior outcomes with steroid antibiotic is unclear, although in 1 of the stud.
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Synopsis Use of Seretide and Symbicort in patients with chronic obstructive pulmonary disease COPD ; is likely to lead to improved adherence to therapy in patients stabilized on both inhaled corticosteroids and long-acting beta-2 agonists, according to the results of a review published in the March 2004 issue of the Drug and Therapeutic Bulletin DTB ; . The Consumer group conducted a review of the two fixed-dose combination inhalers to examine their role in the management of patients with COPD. They concluded that the cost of both preparations were about the same if not less than the combined costs of their individual components given via separate inhalers, but that their use may lead to improved compliance. However the DTB highlights that there are no published studies to support their conclusion.
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