The University Health Insurance Plan is a compulsory health insurance plan for all international students, exchange students, new landed immigrants and returning Canadian students who are not covered by OHIP. During the orientation period, ISC offered three sessions to help new international students understand how to access the health care system in Ontario. These sessions were well received and attended by students. ISC not only provides UHIP service to students and dependants, but also plays a leadership role in staff training, distributing education materials and trouble shooting among different departments related to UHIP administration on campus. In 2001-2002, 3, 501 registrants are on ISC's UHIP database.
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Executive Committee of Novartis. From 2000, he held the position of Head of Legal and General Affairs. His responsibilities were extended to include Corporate Intellectual Property and Corporate Health, Safety & Environment as well as from 2004, Corporate Risk Management and from 2005, Public Affairs and the functional reporting of Group Quality Operations. Since May 2006, Urs Baerlocher has been Head of Legal and Tax Affairs. Raymund Breu, Ph.D., Swiss, age 61. Raymund Breu graduated from the Swiss Federal Institute of Technology ETH ; in Zurich, Switzerland, with a Ph.D. in mathematics. In 1975, he joined the Treasury Department of the Sandoz Group, and, in 1982, became the Head of Finance for the Sandoz affiliates in the UK. In 1985, he was appointed Chief Financial Officer of Sandoz Corporation in New York, where he was responsible for all Sandoz Finance activities in the US. In 1990, he became Group Treasurer of Sandoz Ltd., Basel, Switzerland, and, in 1993, Head of Group Finance and Member of the Sandoz Executive Board. Following the formation of Novartis in 1996, Raymund Breu assumed his current position as Chief Financial Officer and member of the Executive Committee of Novartis. He is also a member of the Board of Directors of Swiss Re, the SWX Swiss Exchange and its admission panel, and the Swiss takeover commission. Juergen Brokatzky-Geiger, Ph.D., German, age 54. Juergen Brokatzky-Geiger graduated with a Ph.D. in Chemistry from the University of Freiburg, Germany in 1982. He joined Ciba-Geigy Ltd. in 1983 as a Laboratory Head in the Pharmaceuticals Division. After a job rotation in Summit, New Jersey from 1987 to 1988 he held positions of increasing responsibility in Research and Development R&D ; including Group Leader of Process R&D, Head of Process R&D and Head of Process Development and Pilot Plant Operations. During the merger of Ciba-Geigy and Sandoz in 1996, Juergen Brokatzky-Geiger was appointed Integration Officer of Technical Operations. Thereafter, he became the Head of Chemical and Analytical Development and served as the Global Head of Technical R&D from 1999 to August 2003. Juergen Brokatzky-Geiger was appointed to his present position as Head of Human Resources on September 1, 2003. He has been a member of the Executive Committee of Novartis since January 1, 2005. Paul Choffat, J.D., Swiss, age 57. Paul Choffat holds a J.D. from the University of Lausanne, Switzerland, and an M.B.A. from the International Institute for Management Development IMD ; in Lausanne. He started his professional career with Nestl in Zurich, Switzerland, and London, UK. From 1981 to 1985, e he was a project manager at McKinsey & Company in Zurich. Between 1987 and 1994, Paul Choffat held a number of senior positions at Landis & Gyr in Zug, Switzerland, where he became a member of the Executive Board and Head of the Communications Division. In 1994, he moved to Von Roll in Gerlafingen, Switzerland, as CEO. Paul Choffat joined Sandoz Ltd. in 1995 as Head of Management Resources and International Coordination. He subsequently became a member of the Executive Board and was responsible for Group Planning and Organization. During the Novartis merger he headed the Integration Office. In 1996, Paul Choffat returned to line management as CEO of Fotolabo SA, Montpreveyres-sur-Lausanne, Switzerland, where he remained for three years before becoming an entrepreneur and private investor in 1999. He rejoined Novartis in January 2002 as Head of Novartis Consumer Health and member of the Executive Committee of Novartis. Thomas Ebeling, German, age 47. Thomas Ebeling graduated from the University of Hamburg, Germany with a degree in psychology. From 1987 to 1991, he held several positions of increasing responsibility at Reemstma Germany. In 1991, he joined Pepsi-Cola Germany as Marketing Director. He became Marketing Director for Germany and Austria in 1993, and was National Sales and Franchise Director for Pepsi's retail and on-premise sales from 1994. He then served as General Manager of Pepsi-Cola Germany. In 1997, Thomas Ebeling joined Novartis as General Manager of Novartis Nutrition for Germany and Austria. After serving as CEO of Novartis Nutrition worldwide, he became CEO of Novartis Consumer Health Division and Chief Operating Officer of Novartis Pharma AG before attaining his present position in 2000. He has been a member of the Board of Directors of Idenix Pharmaceuticals Inc. since 2003. Mark C. Fishman, M.D., American, age 55. Dr. Fishman graduated with a B.A. from Yale College in 1972 and an M.D. from Harvard Medical School in 1976. He was appointed President of the Novartis Institutes 139.
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All-trans-retinoic-acid increases UVB-induced apoptosis of keratinocytes in in vitro reconstructed human epidermis P Mrass, 1 M Rendl, 1 M Mildner, 1 C Ballaun, 1 B Lengauer1 and E Tschachler1, 2 1 Department of Dermatology, Division of Immunology, Allergy, and Infectious Diseases, University of Vienna Medical School, Vienna, Vienna, Austria and 2 CE.R.I.E.S, Neuilly, France We have shown in the past, that all-trans-retinoic-acid ATRA ; -treatment of primary keratinocytes KC ; in monolayer-culture leads to an upregulation of several pro-apoptotic caspases, without inducing apoptosis. However, in contrast to untreated KC, KC after ATRA-treatment were highly susceptible to UV-induced apoptosis. Because retinoids may act differently in vitro and in vivo, we studied their effect on differentiating KC-cultures mimicking the in vivo situation. ATRA-treatment of these skin equivalents SE ; by itself induces apoptosis in up to 30% of the cells. UVB-irradiation 30 mJ cm2 ; of ATRA-treated SE further increased KC-apoptosis up to 100%. By contrast, in DMSOtreated SE only about 10% apoptotic KC, restricted to the basal layer, were observed after irradiation. Because p53 plays a central role in UVB-induced apoptosis, we investigated whether ATRA also influences p53-expression of KC. In DMSO-treated SE, p53 was found almost exclusively in basal KC, while after ATRA-treatment p53 could be also detected in suprabasal layers, both before and after UVB-irradiation. This expression-pattern correlated to the distribution of apoptotic KC observed after UVB-treatment. Furthermore, both the p53-inhibitor alpha-pifithrin, and the pancaspase-inhibitor zVAD strongly reduced UVB-induced apoptosis, indicating that regulation of p53expression participates in the ATRA-mediated sensitization to UVB. Taken together, our data suggest that in SE suprabasal KC lose their potential to undergo UVB-induced apoptosis. Furthermore, we show that ATRA-treated KC of all epidermal layers are sensitized to UVB-mediated apoptosis, probably via upregulation of p53-expression.
We all manage to try and keep up-to-date with the literature by skimming through the abstracts of papers, and although Bandolier seeks to provide help and support for its readers it sometimes has to reveal unpalatable truths that disturb the reader's equanimity . It is almost 10 years since the proposal for more informative abstracts of clinical articles was published [1]. Yet still many articles do not carry the type of structured abstract recommended by the working group for critical appraisal of medical literature. An excellent study of "Methodology and overt hidden bias in reports of 196 double-blind trials of non-steroidal anti-inflammatory drugs in rheumatoid arthritis" by Peter Getzche published in 1989 [2] reported a number of defects in the trials reviewed. The most worrying statement was that "doubtful or invalid statements were found in 76% of the conclusions or abstracts. Bias consistently favoured the new drug in 81 trials and the control in only one trial." This message was reinforced by the article about assessing quality of reports [3] which was reviewed inBandolier 17. The additional issue of the need to beware relative risk reduction as a way of presenting information was described in detail in Bandolier 21. Rules for abstract reading should therefore be: 1 2 If the abstract is not structured, be very cautious. If the abstract of a trial does not describe randomisation, beware. If the results are only expressed in terms of `p' values or relative risk reductions, watch out and mexitil.
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Kevin Irvine followed up by saying that a bullet point summary of what was discussed at the Transition Committee meetings would be helpful. Since the committee was on the topic of communication, Kimberly Robb reminded the members that she is the liaison between the two committees. She noted that she brought the Ad Hoc Committee's suggestion for four 4 ; , five-hour public hearings to the last Transition Committee meeting. In doing so, members of the Transition Committee expressed concern over the amount of staff time that would be used for the public hearings and suggested that there be four 4 ; , two-hour public hearings and if more time was needed for public comment, additional meetings could be scheduled. Committee members were opposed to the two-hour hearings because they feel that there needs to be enough time to allow people to express their concerns regarding the transition process. They also feel that many people will come to the hearings and will be looking for reassurance that the service will not change. The committee was in agreement that it would be a reasonable compromise to have four 4 ; , three-hour public hearings. Melinda Metzger noted that there would be other ways for people to provide comment, such as a website. Mary Beth Clark added that prior to the hearings it would be a good idea to develop a bullet point summary of the proposed paratransit plan. Ad Hoc Committee Schedule: The committee spent time discussing their role in relation to the Transition Committee and created a list of tasks that need to address during upcoming meetings. The following is a list of tasks the committee deemed necessary to address: Specifying locations and dates for the public hearings Developing the structure for the public hearings Brainstorming and addressing questions for the FAQ sheet Selecting agencies that will field questions and provide information regarding the transition process Establishing a telephone number for people to call with questions Coordinating and organizing public information websites, newsletter, . ; Drafting a timeline of things that will occur over the next few years All of the committee members felt that their top priority should be developing methods to keep communication with the public open. This will consequently be our main subject of discussion for the next few meetings. All members agreed that although the previously noted tasks are important, they are only secondary to the committee's first priority. Frequently Asked Questions FAQ ; : Pace staff distributed a draft copy of the FAQ sheet for the committee to review. Ray Campbell suggested that the Ad Hoc Committee set a policy that all documents distributed during a committee meeting should first be sent to all committee members via e-mail. Mary Beth Clark apologized and explained that the draft was only just completed and approved that morning. As an accommodation, Ms. Clark read the document aloud, because axalt migraine medication.
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SEAN M. HANDLER, advokat i firmaet, modtog sin juridiske embedseksamen cum laude fra Temple University School of Law. Hr. Handler modtog sin bachelorgrad fra Colby College med udmrkelse i amerikanske studier. Han har beskikkelse til at pr aktisere i delstaten Pennsylvania og har bestalling til at praktisere for den amerikanske District Court for det stlige distrikt i Pennsylvania. Fr han kom til Schiffrin & Barroway, arbejdede hr. Handler hos Reed Smith, LLP i Philadelphia. Hr. Handler koncentrerer sit arbejde om retssager vedr. vrdipapirer og arbejder i firmaets afdeling for hovedsagsgere, hvilket involverer kontakt med klienter, retssagsstrategi samt hovedsagsgerproblemer. I denne rolle har hr. Handler assisteret partner Stuart Berman i at lede de retssager, firmaet ptager sig som advokat for hovedsagsgere og individuelle klienter at fungere som hovedsagsgere i vigtige sager, som f.eks. Sagen vedr. Tenet Healthcare Corp. Securities Litigation, nr. CV-02-8462-RSWL C.D. Ca. 2002 ; , Sagen vedr. Interpublic Securities Litigation, nr. 02 Civ. 6527 S.D.N.Y. 2002 ; , State of New Jersey and Its Division of Investment v. Sprint Corporation, et al., No. 03-2071-JWL D. Kan. 2003 ; , Sagen vedr. Ariba Inc. Securities Litigation, Master File No. 03-00277 JF N.D. Cal. 2003 ; og Sagen vedr. Autobytel, Inc. Securities Litigation, No. CV04-8987 MMM JWJx ; C.D. Cal. 2004 ; . JOHN A. KEHOE, advokat i firmaet, bestod sin BA fra Depaul University i 1986 og fik sin kandid atgrad i offentlig administration fra University of Vermont in 1994. Han fik sin juridiske bachelorgrad, magna cum laude, fra Syracuse University College of Law i 1997, hvor han var medredaktr for tidsskriftet Syracuse Law Review, suppleantmedlem i bestyrelsen for Moot Court Board og suppleantmedlem p National Appellate Team. Hr. Kehoe er beskikket til at praktisere i delstaten New York og har tilladelse til at praktisere for den amerikanske District Court for New Yorks sydlige distrikt. Fr han kom til Schiffrin & Barroway, havde hr. Kehoe omfattende erfaring med vrdipapirprocesser som advokat hos Bernstein, Litowitz, Berger & Grossman, LLP, og inden da hos Clifford Chance US LLP. Inden han lste jura, arbejdede hr. Kehoe som politibetjent i Burlington og Brattleboro, Vermont og fungerede som frende politidetektiv i adskillige sager med mere eller mindre alvorlige forbrydelser. Hr. Kehoes praksis fokuserer p retssager vedr. vrdipapirer, og har arbejdet omfattende med partner David Kessler i Sagen vedr. Initial Public Offering Securities Litigation, Master File No. 21 MC 92 SAS ; S.D.N.Y. Dec. 12, 2002 ; , som i jeblikket verserer i det sydlige distrikt i New York.
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On July 23, 2004, Pfizer submitted the agreed revised warning statement based on a request from the FDA, dated March 16, 2004, regarding a diabetes class warning relationship with atypical antipsychotic use. Evidence from clinical trials has consistently demonstrated that Geodon did not adversely affect patients' fasting insulin levels, the insulin resistance index, total cholesterol and triglycerides, and blood-sugar levels. In addition, several published studies indicate that the degree of risks for metabolic complications, including diabetes, can vary considerably among atypical antipsychotics. Pfizer's goal in accepting this labeling is to ensure that physicians and patients are best served by the inclusion of appropriate and correct prescribing information for Geodon. Pfizer has filed a supplemental NDA that contains Geodon's metabolic data, with FDA action expected by mid-November 2004. In a study presented at the 2004 American Psychiatric Association, Geodon reversed some of the negative effects that both olanzapine and risperidone exert on body weight and metabolic parameters. Q13 ; How is Relpax performing? A13 ; Relpax, an oral 5HT 1b 1d agonist for the acute treatment of migraine, had sales of $47 million in the third quarter of 2004, a 204% increase over the comparable period in 2003. Year-to-date sales totaled $114 million, up 102%. The product has been launched in more than 25 countries, including the U.S., Japan, Italy, France, Germany, and Spain. Since its March 2003 launch in the U.S., the largest migraine market, as the seventh triptan in a competitive category, Relpax has already surpassed four of its competitors, including Zomig most recently, and has achieved a 12% share of new prescriptions in September and strong formulary access. Relpax was launched in Japan, the second-largest market, in June 2002 and now has 30% of the triptan market and is the #1 choice of general practitioners. In France, the third largest market, Relpax has a market share of 19% of total migraine prescriptions. The product was approved in August in Canada, the fifth largest triptan market. The proven efficacy of Relpax in early treatment and its effects in patients dissatisfied with other migraine treatments suggest that the potential for growth of Relpax prescriptions is strong. Recent studies presented at international congresses have demonstrated the excellent efficacy and tolerability of Relpax 40 mg. One study showed that more than two-thirds of patients who took Relpax at the start of a headache, when headache pain is mild, were pain-free two hours later. In another study, nearly two-thirds of patients dissatisfied with Maxalg showed a positive response two hours after taking Relpax. Q14 ; How is Celebrex performing? A14 ; Sales of the COX-2-specific inhibitor Celebrex, the world's most-prescribed arthritis and pain-relief brand, grew 14% to $797 million in the third quarter of 2004.
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