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THE IMPACT OF NEONATAL SYMPATHECTOMY ON THE PEPTIDERGIC INNERVATION OF THE RAT HEART J. Kuncov, J. Svglerov, J. Slavkov Department of Physiology, Faculty of Medicine, Charles University, Plze, Czech Republic. Intracerebral administration of 6-hydroxydopamine 6HD ; induces catecholaminergic cell death by reactive oxygen species generation or direct inhibition of the mitochondrial respiratory chain 1 ; . However, in the peripheral nervous system, 6HD effect is generally regarded to be different, leading to transient degeneration of the sympathetic nerve terminals only 2 ; . The aims of our study were to reveal whether repeated administration of 6HD to newborn rats 100 mg kg day on postnatal days 1-7, 14, 21 and 28 ; causes long-term degeneration of the cardiac sympathetic innervation and to characterize the impact of neonatal 6HD treatment on the concentrations of calcitonin gene-related peptide CGRP ; and neuropeptide Y NPY ; in relation to norepinephrine NE ; levels in the heart compartments. Cardiac NE, NPY and CGRP concentrations were determined by radioimmunoassay in 6HD-treated rats and the age-matched controls C ; at the ages of 10, 20, 40, and 90 days. In the atria of 6HD rats, NE levels reached ~50 % of C values at the age of 10 days, they did not exceed 8 % of C postnatal days 20 and 40 and then they increased to ~30 % and ~60 % of C levels at the ages of 60 and 90 days, respectively. In contrast, ventricular NE concentrations of 6HD rats did not exceed 15 % of C values on postnatal day 10 and they were 1-5 % of C levels till the age of 90 days. NPY levels in the 6HD atria were ~40 % of C values on postnatal days 10 and 20 and then they increased, reaching 85 % of C concentrations at the age of 90 days. In the left ventricle, NPY levels did not exceed 30 % of the respective C values throughout the study. Despite marked atrio-ventricular differences in the impact of 6HD on NE and NPY concentrations, CGRP levels had similar developmental patterns in all heart compartments: they represented ~130 % of C values at the age of 10 days, ~400 % on days 20-60 and ~250 % of C on postnatal day 90. In conclusion, repeated administration of 6HD to newborn rats resulted in long-term sympathetic denervation of the ventricles and in the increased CGRP levels in all heart compartments. Different patterns of changes in NE and NPY levels in the atria suggest that the intrinsic ganglionic neurones containing both NE and NPY could compensate the loss of the extrinsic sympathetic nerve fibres. 1. Blum D et al.: Prog. Neurobiol. 65: 135-172, 2001.
Les altrations du potentiel de synthse ou de dgradation des protines dcrites au niveau molculaire et cellulaire ne sont donc pas toujours dtectables au niveau tissulaire l'tat basal, surtout in vivo. Elles peuvent toutefois contribuer expliquer une certaine rduction de la masse protique de certains muscles. Il est maintenant intressant de voir dans quelle mesure les effets dcels dans les tissus ont des rpercussions au niveau de l'ensemble du corps et en particulier comment se traduit la rduction de la masse maigre corporelle amorce ds l'ge de 30 ans par la fonte des protines musculaires chez l'homme and orap.
The article notes that the magnitude of benefit for primary angioplasty over thrombolysis is probably less than 1 to 2 lives saved 100 patients treated and largely depends on the choice of thrombolytic agent, time to treatment, place of treatment, and adjunctive therapy. It suggests that it may be most useful to view these treatments as complementary rather than competitive and concludes "thrombolysis remains a clinically and economically attractive option for the treatment of acute MI that does not require the radical restructuring of health care systems". In a second article on this subject, the authors contend that because primary PCI for ST-segment elevation myocardial infarction STEMI ; has superior outcomes, it should be available to all patients with this condition. The article notes that trials have demonstrated that one life is saved and two other life-threatening complications, including stroke and re-infarction, are prevented for every 50 patients with STEMI treated with primary PCI rather than thrombolytic therapy with only 1 major bleeding episode. It goes on to outline obstacles to instituting PCI as the universal treatment and propose strategies to increase its availability.
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Healthcare AdvisorTM On page 24 of the Managed Care section, under the heading "Making Healthy Decisions, " the term "Making Healthy Decisions" is deleted and replaced with the term "Healthcare AdvisorTM." Minimum Maternity Confinement Benefits Coverage is provided for inpatient hospital services for a mother and newborn child for a minimum of: 1. 48 hours following an uncomplicated vaginal delivery, and 2. 96 hours following an uncomplicated caesarean section Any decision to shorten the minimum confinement period will be made by the attending physician in consultation with the mother. If a shortened confinement is elected, coverage will include one home visit for post-delivery care. Home post-delivery care is defined as health care provided to a woman at her residence by a physician, registered nurse or certified nurse midwife. The health care services provided must include, at a minimum: 1. parent education 2. assistance and training in breast or bottle feeding, and 3. performance of necessary and appropriate clinical tests Any subsequent home visits must be clinically necessary and provided by a licensed health care provider. Coverage for Reconstructive Breast Surgery Members of the Commonwealth Indemnity Plan are eligible for mastectomy benefits. As stipulated by federal legislation, coverage for reconstructive breast surgery in connection with a mastectomy may not be denied or reduced on the grounds that it is cosmetic or that it does not meet the Plan's definition of "medically necessary." You are covered for reconstructive surgery, including reconstruction of the other breast to produce a symmetrical appearance. You are also covered for prostheses and treatment of physical complications of all stages of mastectomy, including lymphedemas. Benefits will be payable on the same basis as any other illness or injury, including the application of appropriate deductibles and coinsurance.
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| Pamelor sexual side effectsPhannacotherapeutic education of physicians during their university training, as well as during postgraduate training, traditionally addresses knowledge about biomedical and -more recently- economic aspects of the treatments. Our results regarding the discrepancy between expectations and actual drug choices suggest that in order to ensure optimal drug choices in practice this approach is not sufficient. Future ; physicians should also learn to utilize their biomedical knowledge and expectations in practice. At the moment, the World Health Organisation is developing pharmacotherapeutic training programmes for medical students which specifically attend to this problem [17]. These programmes adopt a problem-solving approach and focus on skills in applying knowledge. In postgraduate education, it seems important that physicians are confronted with the discrepancies between what they do and what they think they do. The weights physicians apparently attach to certain treatment aspects can be elicited from their actual.
Medical criteria for prophylaxis initiation have not been uniformly developed and are based on not only migraine frequency but disability as well. Due to the nature of a claims database, qualitative effects of the migraine episodes could not be assessed; therefore, the quantity of triptan medication received was used as a proxy to determine if drug prophylaxis was indicated. This may have inappropriately categorized patients with frequent but less-severe migraines and those with infrequent but extremely debilitating migraines. Although we attempted to control for any variation in migraine severity and frequency by the subgroup definition, it is possible that variations in these factors may not have been fully accounted for. Since these are real-world data not derived from a randomized, placebo-controlled trial, it is possible that selection bias may have occurred. Physicians may have based treatment decisions on clinical factors that could not be captured in the claims dataset. By implementing strict inclusion criteria, we attempted to control for this. Patients included in the subgroup analysis were similar with respect to triptan consumption prior to the initiation of prophylaxis therapy. To control for selection bias, we conducted 2 additional analyses using a model that included a propensity score17 and a model based on matched cases. However, the results remained the same, supporting the methodology used and the fact that appropriate inclusion and exclusion criteria were utilized to identify patients that were comparable. This study examined costs and utilization in a managed care health plan that was a mix of HMO and PPO models, and the results may not apply to other health plans. Finally, this model explains a small proportion 12% ; of variation in migraine-related medical cost between migraine patients. There are other factors that influence overall cost in addition to those we were able to determine from a claims dataset. ss Conclusion Migraine is a costly disorder for health plans. Identification of utilization characteristics is useful in developing disease management programs aimed at increasing quality patient care and decreasing overall costs. Since there is a strong correlation between use in the first 6 months following triptan initiation and the entire first year of follow-up, it is possible to identify high triptan utilizers early in treatment. Continuing triptan patients are much more costly than new starts. It is therefore potentially valuable to a health plan to identify patients who would benefit from an intervention program early following triptan therapy initiation. Patients receiving greater than 18 TEs in a 6-month period may benefit from the use of migraine drug prophylaxis. Migraine drug prophylaxis is cost-saving $559.71 per patient in 1998-2001 dollars ; , and an intervention program that increases the use of migraine drug prophylaxis in potential candidates could be cost beneficial and olanzapine.
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CAS REGISTRY NUMBER: 91-59-8 EINECS No. 202-080-4 ECL Serial No. 98-4-25 ECL Serial No. KE-25711 SWISS No. G-43306 ISRAEL No. 20.10 TAIWAN No. 35-01 ECL Toxic Chemical No. 97-1-412 INVENTORY NAME S ; : 2-Naphthalenamine DSL, PICCS, ASIA-PAC ; 2-Naphthylamine English, French ; DSL, EINECS, ECL, TAIWAN ; 2-naphtylamine French ; EINECS ; 2-Naphthylamin German ; EINECS ; 2-naftilamina Spanish ; EINECS ; NAPHTHYLAMIN, B- German ; SWISS ; -NAPHTHYLAMINE PICCS ; NAPHTHYL-2-AMINE PICCS ; Naphthylamine, 2- ISRAEL ; OTHER NAME S ; : -Naphthalenamine 2-Aminonaphthalene C.I. 37270 Fast Scarlet Base B Naphthalen-2-ylamine Naphthalene, 2-aminoUN 1650 UN 1650 DOT ; KOREAN TCCL DESIGNATION: ECL Toxic Chemical No. 97-1-412 This substance and its hydrogen chloride salt. SWISS CLASSIFICATION: Giftliste 1 List of Toxic Substances 1 ; , 13 June 2000. Toxic Category 1 * : Acute oral lethal dose up to 5 mg kg and a possible carcinogen. TAIWAN CLASSIFICATION: This is a Class I and II toxic chemical. Regulated threshold quantity is 50 Kg. Only allowed for testing, research or education purposes. Minimum control level is 1 w w%. ISRAEL CLASSIFICATION: Proposed Israel Hazardous Substances List, 2001. This list has not been finalized. Classification Regulations: This substance is exempt from reporting under the Hazardous Substances Law of 1993 if the reportable quantity is lower than 0.1 kg. FORMULA: C10H9N and omeprazole.
Description. Vanadium is a trace mineral that may be life-essential. Actions and Pharmacology. Research suggests that vanadium is essential to normal insulin function. Evidence is accumulating, showing that vanadium mimics insulin action in isolated cell systems. Usage and Dosage. Range of 10 mcg to 1800 mcg. is considered safe. However, clinical studies with vanadium compounds have shown benefits in increasing insulin sensitivity in type 2 diabetics at a dosage of 100 milligrams vanadyl sulfate 31 mg elemental vanadium ; daily for up to 4 weeks. Research Summary. Studies demonstrate that vanadium significantly mimics insulin action and lowers plasma glucose at pharmacological doses in animals and humans with diabetes. Contraindications, Precautions, Adverse Reactions, Interactions. No known contraindications at physiologic doses. Adverse reactions of diarrhea, green tongues, nausea, vomiting, and cramps are reported at dosage levels 4.5 to 22.5 mg per day. Ferrous ion, chloride, EDTA, chromium, and aluminum hydroxide may impair absorption of vanadium, for example, psmelor dosing.
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Effects of their compounds and by learning of new clinical uses and markets for its compounds. Drug Pfinder. Drug Pfinder was established to leverage discoveries and expertise from the academic and biotechnology communities to support new lead discovery programs. Novel potential discovery targets often are identified in the academic community; however, scientists lack the resources or experience to translate these targets into new medicines. Through a Drug Pfinder collaboration, the academic scientist gets access to Pfizer's extensive stateof-the-art high throughput screening HTS ; experience, including our compound file comprising millions of unique, drug-like structures. This collaboration also includes financial milestones, dedicated medicinal chemistry to turn ``hits'' into ``leads, '' and a direct link to established teams dedicated to specific disease areas Fig. 4 ; . Of particular interest are targets that have yet to be published and or have established intellectual property, targets in which our collaborator has extensive expertise and assay methods, and targets that may have numerous therapeutic applications or are in newly emerging areas of biology. Ultimately, the goal of a Drug Pfinder partnership is to generate a lead.
The paediatric intensive care audit network PICANet ; was established in 2001 in collaboration with the Paediatric Intensive Care Society. This prospective clinical audit database of all admissions to paediatric intensive care units in England and Wales aims to identify evidence based best practice, facilitate resource planning, and study the epidemiology of paediatric critical illness see picanet ; . The Data Protection Act requires that patients give their consent and trileptal.
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Clinical thyroidology Poster EFFECT OF T4-T3 COMBINATION THERAPY vs. T4 MONOTHERAPY IN PATIENTS WITH HYPOTHYROIDISM. A DOUBLE BLIND RANDOMIZED CROSS-OVER STUDY B. Nygaard1, E. Winther Jensen1, J. Kvetny2, A. Jarlv3, J. Faber1 1 University Hospital, Endocrinology, Herlev 2 Hospital, Endocrinology, Esbjerg 3 University Hospital, Endocrinology, Frederiksberg, Denmark Purpose: To compare the effect of T4-T3 combination therapy versus T4 monotherapy in patients with autoimmune hypothyroidism, on stable T4-substitution therapy Study Design: Double blind, randomized cross-over design. In 59 patients 55 women; aged 46 yrs range 1976 ; TSH at diagnosis 68 mU L 20370 period of stable euthyroidism on T4-substitution 12 months 6180 , 50 microgram of the usual T4 dose were replaced with a tablet containing either 20 microgram of T3 or microgram of T4 for 12 weeks, followed by cross-over for another period of 12 weeks. S-TSH data on T4 and T3 measurements were blinded ; was measured after 4 weeks, and the T4 dose was regulated if needed, intending unaltered TSH levels despite changed medication. Evaluation: blood tests, weight and tests of quality of life QOL ; and depression at base line and after the 2 treatment periods. At the end of the study the patients were asked which treatment period they preferred. Results: 28 59 patients described reduced QOL at base line despite relevant treatment!
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The space-based ELINT demonstrator will pave the way for an operational program to establish and update a detailed global map of radar systems. The ELINT system will have four microsatellites based on CNES Myriade series and be placed in Sunsynchronous low-Earth orbit. They will feature advanced pointing capabilities and dedicated ELINT mission payloads. The DGA French weapons procurement agency ; and CNES French space 8 research agency ; are co-funding the program that costs about euros170, 000. The partners have set up integrated project ownership with shared responsibility. The DGA will be in charge of mission architecture, payloads and user-ground segment while CNES will handle engineering, satellite buses, satellite integration and launch. CNES will also be responsible for some system engineering work orbitography and space-ground interface definition and orap.
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Methods: Pure- tone threshold audiometry PTTA ; was performed in 42 patients before and 565, 64 days mean ; after LTx. Patients were divided in 2 groups and compared, according to therapeutic use of CyA n 18 ; or Statistics used non- parametric Wilcoxon's rank-sum and Mann- Whitney tests. The level of significance adopted was p .005. Results: There was a statistically significant change in PTTA results, particularly in the high frequencies tones, in patients submitted to LTx. In individuals treated with FK audiometric changes were exceedingly more pronounced than that of CyA. See table. Table: PTTA in the right and left ear in the FK group, before and after LTx n 24 ; . Variable 250 500 1000 RIGHT EAR Before Tx 10 5-15 ; 10 5-10 ; 5 5-10 ; 5 5-15 ; 10 5-22.5 15 After Tx 10 10-15 ; 10 5-10 ; 5 5-13.5 ; 5 5-13.7 ; 15 5-30 ; 25 11-39 ; p-value 0.109 1.000 0.608 * 0.019 * LEFT EAR Before Tx 10 5-15 ; 5 5-10 ; 5 0-10 ; 5 1.2-13 ; 10 5-28 ; 20 5-35 ; After Tx 10 10-15 ; 10 5-10 ; 5 0-10 ; 5 5-15 ; 15 6-30 ; 25 5-40 ; p-value 0.04 * 0.033 * 0.480 0.09 0.042 * 0.07 A 2-month trial of total parenteral nutrition TPN ; and medium-chain triglyceride diet MCT ; failed, and another paracentesis of 4.6L was needed. Pedal lymphangiogram was negative. Subcutaneous octreotide OCT ; was started, escalating to 0.3mg BID by 2 weeks. At 4 weeks there was full clinical resolution and the patient resumed a normal diet without relapse. At 8 weeks, OCT was reduced to 0.2mg BID. Symptoms recurred 9 days later. A dose increase to 0.3mg BID for 3 weeks did not help, prompting a further increase to 0.5mg BID, resulting in total clinical resolution after 3 weeks. This time we proceeded with a slow, more deliberate taper over months, with success. Results: There have been an additional eleven cases of chylous ascites reported in live kidney donors to date, all after LDN. Interestingly we find no case of chylous ascites ever reported after conventional open nephrectomy. As its use becomes prevalent, unusual complications of LDN may crop up. Meticulous reporting of such complications and their therapeutic options will be critical to propitious patient care. Note from the publisher: An image was submitted to support this abstract. For technical reasons.
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