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Aggravated by Norplant. At the same time, many women, both in the First and Third World, have not been fully informed about Norplant's side effects. Many women do not have the time or the financial resources to visit a health centre to address complications or to have Norplant removed. Tracking women who have been implanted is also difficult because often records are incomplete or not kept long enough, or because women migrate. Doctors and users readily admit that some women do not have the implant removed until long after its five-year term has expired, if ever. The long-term side effects and the effects of Norplant on the children born to women who are using, or have used Norplant, are as yet unknown. These are compelling reasons for women to choose an alternative, safer method of contraception. By 1995, four class-action suits, involving about 8, 000 women, had been filed in the United States against Wyeth-Ayerst, the manufacturer, for complications caused by Norplant. Norplant becomes a costly contraceptive if it is not used for the full five years. This high cost may lead health workers to discourage the removal of Norplant before its five-year term is completed. Many women have reported that removal upon demand is not widely or easily available. Thailand is one country in which women have been told that Norplant will not be removed for "minor" side effects. There is increasing evidence that Norplant is being used, in both the industrialized world and in the Third World, as a coercive measure to stop certain women from having children. In the United States, proposed legislation in Arizona, Washington, Florida and South Carolina would link women's welfare benefits to their agreement to use Norplant. In Washington, legislators have proposed the involuntary insertion of Norplant in mothers of fetal alcohol syndrome or drug-addicted babies. And in South Carolina, if the legislation is approved, no welfare payments will be made to women with two or more children unless they agree to have Norplant inserted. In Indonesia, women must agree to have Norplant inserted or their partners must agree to be sterilized ; before they can receive an abortion. Where contraceptive choice is available to some degree, Norplant is offered at no expense to most rural women, though they are told that it is among the most expensive contraceptives available. Promoted as a symbol of middle or upper-class status, which can have appeal among rural and urban poor women, Norplant is attracting increasing numbers of women. It is no coincidence that poor women in the First and Third World are not required to pay for Norplant nor for several other long-term, provider-controlled methods of birth control. For the proponents of population control, Norplant represents a method of controlling women's reproduction without a chance of "user failure.
Classical and contemporary studies of olfaction have focussed on the role of the glomerulus in processing information about the molecular qualities of odors, but changes in the physical properties of airborne odorants also affect behavior, and thus influence the brain's perception of olfactory input. In moths, continuous and intermittent stimulation with the same odor evoke two distinct flight behaviors, but the neural basis of this differential response is unknown. Here we show that certain glomerular projection neurons PNs ; exhibit context-dependent odor responses that are shaped in several ways by a bicuculline-sensitive GABA receptor. Pharmacological dissection of PN responses suggests that bicuculline blocks a GABAA-type chloride channel receptor on the dendrites of PNs, and this receptor plays a critical role in shaping glomerular output. While the firing patterns in PNs are strongly dependent on GABAergic inhibition, they are also modulated by the temporal pattern of the odor stimulus itself. Brief, repetitive stimulus pulses evoke fast inhibitory potentials followed by discrete bursts of firing that are time-locked to the stimulus pattern. In contrast, the response to a single, prolonged pulse with the same odor is a series of slow oscillations underlying irregular firing; a pattern more indicative of a temporal spike code. Bicuculline destroys the timing of both response types, suggesting that a GABAA -type receptor underlies both coding mechanisms. These results provide the first evidence that glomerular output neurons could employ more than one coding scheme to represent a single olfactory stimulus. Moreover, these output neurons integrate information about chemical identity as well as information about changes in the physical environment bearing the odor stimulus. When combined with the behavioral evidence, these data suggest that context-dependent odor responses evoke different perceptions in the brain that provide the animal with important information about the temporal variations that occur in natural odor plumes. Supported by NIH grant AI-23253 to J.G.H. 90. Dynamic models of receptor transduction and olfactory coding in the insect antennal lobes and tagamet. The only difference between retkn-a micro look like when you should continue treatment.

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