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Polymeric weak-base anion exchange packing for gradient separation of proteins and DNA oligomers. Limited porosity allows separation of large DNA fragments. pH stable from 0 to 14. Check ; YES if: There is documentation in the medical record that the member received one. c ; Check ; NO if: There is no documentation in the medical record that the member received one. d ; If NO, then continue to item 12a ; . Check ; YES if: There is documentation that the member has pre-existing nephropathy. This would be in progress notes, consults, or possibly lab results. Skip to question 13 if answered "yes" to evidence of pre-existing nephropathy. Pre-existing nephropathy includes: lab with positive proteinuria, microalbuminuria, or urine protein; acute renal failure, chronic renal failure, renal insufficiency, end-stage renal disease, or any type of dialysis. e ; Check ; YES if: There is NO documentation that the member took insulin during study period. Evidence of insulin use would be in progress notes, telephone notes, or prescription flow sheet. f ; Check YES ; if: The most recent HbA1C was less than 8.0%. g ; Check ; YES if: There is documentation that the member was screened for nephropathy during year prior to study year and the screen showed no evidence of nephropathy. This would be in progress notes, lab section, or consults. A lack of evidence of nephropathy would include microalbumin values WNL, for example, florida lawyer serzone. Maher CF, O'Reilly BA, Dwyer PL, et al. Pubovaginal sling versus transurethral Macroplastique for stress urinary incontinence and intrinsic sphincter deficiency: A prospective randomised controlled trial. BJOG: an International Journal of Obstetrics and Gynaecology 2005; 112 6 ; : 797801. Andersen RC. Long-term follow-up comparison of Durasphere and Contigen in the treatment of stress urinary incontinence. Journal of Lower Genital Tract Disease 2002; 6 4 ; : 23943. Lightner D, Calvosa C, Andersen R, et al. A new injectable bulking agent for treatment of stress urinary incontinence: Results of a multicenter, randomized, controlled, double-blind study of Durasphere. Urology 2001; 58 1 ; : 1215. Corcos J, Collet JP, Shapiro S, et al. Multicenter randomized clinical trial comparing surgery and collagen injections for treatment of female stress urinary incontinence. Urology 2005; 65 5 ; : 898904. Lee PE, Kung RC, Drutz HP. Periurethral autologous fat injection as treatment for female stress urinary incontinence: a randomized double-blind controlled trial. Journal of Urology 2001; 165 1 ; : 1538. Chrouser KL, Fick F, Goel A, et al. Carbon coated zirconium beads in beta-glucan gel and bovine glutaraldehyde cross-linked collagen injections for intrinsic sphincter deficiency: Continence and satisfaction after extended followup. Journal of Urology 2004; 171 3 ; : 11525. Haab F, Zimmern PE, Leach GE. Urinary stress incontinence due to intrinsic sphincteric deficiency: experience with fat and collagen periurethral injections.[erratum appears in J Urol 1997 Jul; 158 1 ; : 188]. Journal of Urology 1997; 157 4 ; : 12836. Faerber GJ, Belville WD, Ohl DA, et al. Comparison of transurethral versus periurethral collagen injection in women with intrinsic sphincter deficiency. Techniques in Urology 1998; 4 3 ; : 1247. Schulz JA, Nager CW, Stanton SL, et al. Bulking agents for stress urinary incontinence: Short-term results and complications in a randomized comparison of periurethral and transurethral injections. International Urogynecology Journal 2004; 15 4 ; : 2615. Henalla SM, Hall V, Duckett JR, et al. A multicentre evaluation of a new surgical technique for urethral bulking in the treatment of genuine stress incontinence. BJOG: an International Journal of Obstetrics and Gynaecology 2000; 107 8 ; : 10359. Usman F and Henalla S. A single transurethral Macroplastique TM ; injection as primary treatment for stress incontinence in women. Journal of Obstetrics and Gynaecology 1998; 18 1 ; : 5660. Gurdal M, Tekin A, Erdogan K, et al. Endoscopic silicone injection for female stress urinary incontinence due to intrinsic sphincter deficiency: Impact of coexisting urethral mobility on treatment outcome. Urology 2002; 60 6 ; : 101619. Sheriff MK, Foley S, McFarlane J, et al. Endoscopic correction of intractable stress incontinence with silicone micro-implants. European Urology 1997; 32 3 ; : 2848. Radley SC, Chapple CR, Mitsogiannis IC, et al. Transurethral implantation of Macroplastique for the treatment of female stress urinary incontinence secondary to urethral sphincter deficiency. European Urology 2001; 39 4 ; : 3839. Tamanini JT, D'Ancona CA, Tadini V, et al. Macroplastique implantation system for the treatment of female stress urinary incontinence. Journal of Urology 2003; 169 6 ; : 222933. Tamanini JT, D'Ancona CA, Netto NR Jr. Treatment of intrinsic sphincter deficiency using the Macroplastique Implantation System: two-year follow-up. Journal of Endourology 2004; 18 9 ; : 90611. Barranger E, Fritel X, Kadoch O, et al. Results of transurethral injection of silicone micro-implants for females with intrinsic sphincter deficiency. Journal of Urology 2000; 164 5 ; : 161922. Koelbl H, Saz V, Doerfler D, et al. Transurethral injection of silicone microimplants for intrinsic urethral sphincter deficiency. Obstetrics and Gynecology 1998; 92 3 ; : 3326. Harriss DR, Iacovou JW, Lemberger RJ, et al. Peri-urethral silicone microimplants Macroplastique TM for the treatment of genuine stress incontinence. British Journal of Urology 1996; 78 5 ; : 7228. Richardson TD, Kennelly MJ, Faerber GJ. Endoscopic injection of glutaraldehyde cross-linked collagen for the treatment of intrinsic sphincter deficiency in women. Urology 1995; 46 3 ; : 37881. Cross CA, English SF, Cespedes RD, et al. A followup on transurethral collagen injection therapy for urinary incontinence. Journal of Urology 1998; 159 1 ; : 1068. Khullar V, Cardozo LD, Abbott D, et al. GAX collagen in the treatment of urinary incontinence in elderly women: A two year follow up. British Journal of Obstetrics and Gynaecology 1997; 104 1 ; : 969. Bent AE, Foote J, Siegel S, et al. Collagen implant for treating stress urinary incontinence in women with urethral hypermobility. Journal of Urology 2001; 166 4 ; : 13547. Monga AK, Robinson D, Stanton SL. Periurethral collagen injections for genuine stress incontinence: A 2-year follow-up. British Journal of Urology 1995; 76 2 ; : 15660. Stanton SL and Monga AK. Incontinence in elderly women: Is periurethral collagen an advance? British Journal of Obstetrics and Gynaecology 1997; 104 2 ; : 1547. Gorton E, Stanton S, Monga A, et al. Periurethral collagen injection: A long-term follow-up study. BJU International 1999; 84 9 ; : 966 71. Corcos J and Fournier C. Periurethral collagen injection for the treatment of female stress urinary incontinence: 4-year follow-up results. Urology 1999; 54 5 ; : 81518. Herschorn S, Steele DJ, Radomski SB. Followup of intraurethral collagen for female stress urinary incontinence. Journal of Urology 1996; 156 4 ; : 13059. Herschorn S and Radomski SB. Collagen injections for genuine stress urinary incontinence: Patient selection and durability. International Urogynecology Journal 1997; 8 1 ; : 1824. Winters JC, Chiverton A, Scarpero HM, et al. Collagen injection therapy in elderly women: Long-term results and patient satisfaction. Urology 2000; 55 6 ; : 85660.
October 31, 2002 IMPORTANT SAFETY INFORMATION REGARDING MEDICATION ERRORS RESULTING FROM CONFUSION BETWEEN SEROQUEL AND SERZONE-5HT2 Dear Health Care Professional: Please be aware of the following: Potential for medication error resulting from confusion between Seroquel and Serzone-5HT2 sound-alike medications ; . AstraZeneca Canada Inc. has received one report of a medication error in Canada involving confusion between its atypical antipsychotic SEROQUEL quetiapine fumarate ; indicated for the management of the manifestations of schizophrenia, and SERZONE-5HT2 nefazodone hydrochloride ; , manufactured by Bristol-Myers Squibb, indicated for the symptomatic relief of depressive illness. This report resulted from a dispensing error. SERZONE-5HT2 was prescribed, however SEROQUEL was received by the patient. No other reports of medication errors between these two drugs have been received by AstraZeneca Canada Inc. or Bristol-Myers Squibb Canada Inc., at the time of writing this letter. This letter is being issued to health care professionals and all Canadian hospitals, and relevant professional associations advising them of the possibility and potential seriousness of confusing SEROQUEL and SERZONE-5HT2. A similar letter was sent to healthcare professionals in the U.S.A. and a safety alert letter was also posted on the FDA website on May 20, 2002. Accountable Manager Katie Donlevy Date 1.3.07.

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Maintenance therapy to which a patient might be exposed for decades, the potential harm of such exposure can only be guessed. When the drug is immediately lifesaving, the risk may be acceptable, but when it offers only a modest enhancement to existing therapies, evidence-based medicine would urge caution. It is best to do no harm. Reluctance to add new drugs when there are established therapies for the same condition is also rational economic behavior. The potential risks and uncertain benefits may impose costs in the form of risk.24 One group brought up a perceived connection between the FDA and the pharmaceutical industry and the resultant impact this was believed to have on that agency's ability to provide impartial expert opinions on products reviewed. This was relevant to a discussion of a new black box warning put out by the FDA on an older antidepressant Serzone. Although Health Canada recently removed it from the market in Canada and the manufacturer removed it from the market in Europe, the FDA did not remove this drug from the U.S. market. Another discussion involved the desirability of covering drugs that provided no unique benefit to patients other than convenience. An example of such a drug is Seasonale, a new three-month course of oral contraceptive that allows the user to restrict menses to four times per year. The mix of hormones in Seasonale can be obtained from other available drugs, and simply taking the alternative drugs without using the placebo pills can mimic the three-month supply. This discussion pitted one person opposed to making formulary additions for this type of convenience against another who considered having Viagra on the formulary roughly the same and felt to refuse Seasonale would be inconsistent with that precedent. Concern over the convenience and cost to patients when using the pharmacy benefit surfaced in several meetings. For example, in one meeting the copay advantages to members of a new combination diabetes drug, Avandamet, was mentioned. This new drug combines two drugs that are already separately available, but having them combined under a single copay would save members money at the pharmacy. In another, P&T committee members expressed concern that patients might be confused when required to obtain prior authorization for an injectable drug and then have to write a large check at the pharmacy when this was not required for other drugs. While this was done to their benefit design and singulair.

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E-mycin, ery-tab fluconazole diflucan fluphenazine prolixin itraconazole sporanox ketoconazole nizoral medications for depression such as amitriptyline elavil ; , amoxapine asendin ; , clomipramine anafranil ; , desipramine norpramin ; , doxepin adapin, sinequan ; , imipramine tofranil ; , maprotiline ludiomil ; , nefazodone serzone ; , nortriptyline pamelor ; , protriptyline vivactil ; , and trimipramine surmontil medications for irregular heart beats such as amiodarone cordarone ; , disopyramide norpace ; , quinidine quinidex ; , procainamide procanbid, pronestyl ; , and sotalol betapace mesoridazine serentil perphenazine trilafon prochlorperazine compazine promethazine phenergan protease inhibitors such as indinavir crixivan ; and ritonavir norvir sertindole serlect sparfloxacin zagam thioridazine mellaril thiothixene navane trifluoperazine stelazine or troleandomycin tao. ARMSTRONG AJ. Effects of pine afforestation on native niota and conservation evaluation of afforestable grasslands in Montane areas of South Africa. Ph.D., 1996. 182 pp. Promotor: Dr HJ van Hensbergen and tamoxifen. Willis how the dea learns about doctors who are diverting prescription drugs. Of inscriptions patients and tiazac paxil serzone zoloft actos bactroban vary depending in a secondary care setting and temazepam. The mean age at entry was 82 range, 75-101 ; years. During the 7, 123.8 person-year follow-up, 134 first hip fractures were identified, giving the overall incidence of 18.8 per 1, 000 person-years. The incidence of hip fracture increased with age and female sex table 1 ; . The mean follow-up interval was 4.4 years, with a maximum of 6.3 years.

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Culture is an entity which is difficult to define in scientific terms. It can mean different things to different people. For our purpose, culture embodies not just the set of values but also particular diets and lifestyles that a cultural group embraces. No culture exists in isolation. Given the ease of communication and intercontinental travel today, populations are constantly interacting. This fluid state of cultural evolution means constant modifications of dietary, lifestyle, and even reproductive choices. Hence, what we describe as true today may no longer be valid within the next decade. For the moment, it can be asserted that the majority of Asian women in Asia embrace the menopause with stoic and tranquil acceptance, treating it as another milestone in the progression of life. Indeed, the term used in Chinese is simply "a change in life phase." Hence, most Asian women look upon the problems that accompany the onset of menopause as an inevitable part of aging to be embraced, rather than struggled against. It is not easy to conduct a good study on cultural aspects of menopause, as many of the nuances may be lost in translation. It is also important and tiazac.
Learn more about other dangerous pharmaceutical drugs and pharmaceutical negligence: accutane acetaminophen arava baycol celebrex crestor duragesic pain patch enbrel ephedra heart stent meridia neurontin oxycontin paxil ppa prempro premarin remicade rezulin serzone smith and nephew knee replacement stadol taxus coronary stent thimerosal vioxx zyprexa call brown & crouppen at 1-800-536-help for your free legal consultation or save time with our online contact form. The food and drug administration recommends the new warnings appear on antidepressant drugs and tobradex. Nisms behind the increased risk associated with some of these drugs? ann babbitt: Some of these medications, especially the anticonvulsants, appear to interfere with calcium and vitamin D metabolism.19 Vitamin D may be the missing link in some of these. Others, including the glucocorticoids, may have additional effects on sex hormones, parathyroid hormone, kidney, and bone, and contribute to bone loss through these pathways.20.
In part to inadequate vitamin D status, and if we act on that knowledge, the medicine of the future could look extremely different from that of today. Robert P. Heaney, MD Creighton University Medical Center Omaha, Neb and toprol. Cases, but at present is still investiga tional. Pharmacologic agents have small effect on the carcinoid syndrome. The treatment of choice is surgery judicious and aggressive"aimed at the removal of all tumorous tissue.

Sedation, and weight gain.35 Sexual dysfunction is not a side effect of this agent. Drug interactions with mirtazapine have not been studied systematically Table 2 ; . The recommended starting dosage is 15 mg at bedtime, which may be titrated up to 45 mg daily, if needed Table 1 ; . Nefazodone In January 2002, the FDA and the manufacturer of nefazodone Sedzone ; added a black box warning to the prescribing information concerning rare cases of liver failure.36 The reported rate is one per 250, 000 to 300, 000 patient-years. Physicians should counsel patients who are taking nefazodone to be alert for signs and symptoms of liver failure, including jaundice, anorexia, gastrointestinal problems, and malaise. Nefazodone therapy should be avoided in patients with active liver disease or elevated serum transaminase levels, and discontinued in patients whose alanine aminotransferase or aspartate aminotransferase levels are three times the upper limit of normal or more. There is no recommendation, however, for periodic testing of liver function. Antidepressant-Induced Sexual Dysfunction Sexual dysfunction, usually delayed ejaculation or anorgasmia, may occur in both men and women who are taking SSRIs and venlafaxine. These patients have several options: reducing the dosage, switching to another agent, or adding another agent to overcome the sexual side effects.37 Sexual dysfunction typically reverses within one to three days after discontinuation of the antidepressant and returns on reintroduction. Recovery after withdrawal from fluoxetine may occur within one to three weeks. Uncontrolled studies and case reports37 suggest that the addition of bupropion Wellbutrin ; , cyproheptadine Periactin ; , nefazodone, or mirtazapine may decrease sexual side effects. In patients with antidepressant-induced erectile dysfunction, sildenafil Viagra ; may be useful if the patient has no history of angina and is not taking nitrates.37 Treatment Resistance: Augmentation and Switching Ten to 30 percent of patients taking antidepressants are partially or totally resistant to the treatment.38 Some patients also may experience breakthrough or recurrence of depression while taking the medication. Strategies for dealing with these problems include optimizing the and trazodone and serzone.
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Pennsylvania. These parameters will also be used in Santhera's upcoming U.S. Phase III trial to demonstrate efficacy of SNT-MC17 idebenone. Santhera plans to start the U.S. Phase III study with SNT-MC17 idebenone this summer. We expect to enrol over 200 patients into several clinical centers nationwide. The wellcontrolled study will test various dose levels of SNT-MC17 idebenone including the high dose levels that are currently studied in the collaborative trail with the NIH. SNT-MC17 idebenone will be given in a fixed number of tablets per patient using two different tablet strengths. The trial will be conducted under the super vision of physicians who are renowned FRDA experts. Their expertise and the proven safety record of Idebenone are expected to attract highly motivated FRDA patients to participate in this pivotal study. Current regulatory status of Idebenone in the U.S. At present, Idebenone has not been approved by the Food and Drug Administration FDA ; . Moreover, the FDA does not consider Idebenone to be a dietary supplement because the compound does not meet the statutory definition of a dietary supplement as defined in 21 U.S.C. 321 ff ; 7. Santhera's cur rent ef forts to develop SNT-MC17 idebenone in well controlled and FDA-approved clinical trials are pivotal steps in gaining regulatory approval for Idebenone. Santhera has initiated a comprehensive clinical development program in the U.S. and Europe aiming at obtaining this regulatory approval. Once SNT-MC17 idebenone is approved and registered it will be finally available to FRDA patients as prescription drug and will become fully eligible for reimbursement by health care insurers. The continuous support of several organizations representing FRDA patients and their families as well as the enthusiasm of patients. Food and drug administration - narrowed by 'serzone drug ; ' get alerts on food and drug administration receive newstracker e-mail alerts on topics covered on this page and triamterene.

Along with 10 newer-generation antidepressant drugs, setzone was linked to the possibility of causing worsened symptoms of depression and increased suicidal tendencies in children and teens.

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Participants Selected members of senior management of the DRAXIMAGE division as designated by the Company. Mr. Jean-Pierre Robert participates in this plan but received no award under the plan in 2005. Dr. Richard Flanagan participated and received an award under the plan in 2005. See "Employment Contracts and Termination of Employment". DRAXIS Pharma, a division of DRAXIS Specialty Pharmaceuticals Inc. Intention In September 2003, the then-existing Equity Participation Plan of DRAXIS Pharma Inc. as of January 1, 2005 known as DRAXIS Pharma, a division of DRAXIS Specialty Pharmaceuticals Inc. ; was terminated and replaced with a Long Term Equity Incentive Plan to provide certain senior management employees of DRAXIS Pharma with a meaningful incentive to increase the value of the Company and to allow management to share in the benefits of that value creation. Mechanism The terms of this plan provide that eligible participants have a right to receive phantom equity shares of DRAXIS Pharma and, subject to approval by the Company's Board of Directors and applicable regulatory authorities, options of the Company. The options are governed by the terms of the Stock Option Plan of the Company see "Incentive Plans - Stock Option Plan" ; . In accordance with a resolution passed by the Board of Directors in March 2005, the Plan was amended so that a participant may only receive the cash value of said phantom equity shares on the plan expiry date or other designated termination event. Prior to said amendment, the Company could elect to pay such value in shares of the Company. However, at the date of the amendment, no such election had been made by the Company. In order for an eligible participant to receive a termination distribution amount with respect to a phantom equity share, certain financial ratios must be met by DRAXIS Pharma. Participants Selected members of senior management of the DRAXIS Pharma division as designated by the Company. Mr. John Durham participates in this plan but received no award under the plan in 2005. Discontinued Plan Equity Purchase Plan Eligible participants in this plan were entitled to purchase on a yearly basis common shares of the Company equal to not more than 40% of their base salary, funded by an interestbearing loan from the Company, with the common shares to be acquired by an open market purchase by a trustee on behalf of the participants. The purchase price was equal to the closing price of the common shares on the TSX or NASDAQ on December 31 of each year, based on a purchase commitment as of December 1 of the prior year. This plan was cancelled by the Board of Directors in 2002 and all outstanding loans granted thereunder were repaid in 2005. Compensation of Directors In 2005, the compensation paid to each director of the Company was revised following a review of the compensation paid to directors. At the request of the Human Resources and Compensation Committee and the Board of Directors, the CEO reviewed management proxy circulars of twelve Canadian companies, as well as a third party review of corporate governance and director compensation in Canada. As of January 1, 2005, each director, other than Dr. Martin Barkin, received an annual honorarium of $17, 500 plus a meeting fee of $1, 500 for each Board of Directors and Committee meeting attended, some via teleconference. In addition, the Chairs of each of the Human Resources and Compensation Committee and the Nominating and Corporate Governance Committee received an annual retainer of $5, 000. The Chairman of the Audit. I on prozac 30mg ; , sezrone 300mg ; , abilify 15mg ; , and some other pills for.

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Purpose of the study: Volumetric capnography is the projection of expired CO2 concentration versus expired volume for every single breath. For many years this method has been used for testing pulmonary function in humans with lower airway disease. In veterinary pulmonary function testing capnography has already been validated in horses. The aim of our study was to evaluate the lung function of awake, spontaneous breathing calves by the use of volumetric capnography. Methods: The study included 25 clinically inapparent calves. Twelve of them were born in a stock with no history of respiratory diseases group 1 ; . Group 2 consisted of 13 animals from different stocks, where the problem of respiratory diseases, especially lower airway affections, was known. All calves were investigated capnographically six times within six months once per month ; . Capnographic measurements were performed with MasterScreen Capno" VIASYS Healthcare, Germany ; . The following indices derived from the volumetric capnogram were calculated: i ; the slopes of the phases II and III, ii ; the ratios of the mixing volume expired between 25 and 50% of the end-tidal carbon dioxide concentration and the inspired volume as well as the mixing volume between 50 and 75% of the end-tidal carbon dioxide concentration and the inspired volume Vm25-50 VTin, Vm50-75 VTin ; , and iii ; the ratio of dead spaces determined either according to Wolff or according to Bohr, respectively, and the tidal volume VD Wolff VT, VD Bohr VT ; . Differences of these indices at the six time points of investigation between the two groups were analysed using the Mann-Whitney-Wilcoxon test P 0.05 ; . Results: Using Impulse Oscillometry as the reference method, peripheral airway obstructions were detected in calves of group 2 despite the absence of clinical symptoms. Using volumetric capnography, the following significant differences between the 2 groups of calves were observed: At five time points, the slope of phase II was significantly flatter and the slope of phase III was significantly steeper in group 2 than those in group 1. Furthermore, Vm25-50 VTin and Vm50-75 VTin were significantly increased at five and six time points, respectively, in group 2. Also, VD Wolff VT and VD Bohr VT were significantly elevated in group 2 compared to group 1 at five time points. Conclusions: Volumetric capnography was found to be suitable for non-invasive lung function testing in spontaneously breathing conscious calves. In the presence of even clinically inapparent peripheral airway obstruction, this technique reflects significant changes in the pattern of expired CO2 concentration and therefore can be recommended for further diagnostic purposes. MEDI 368 Potent and selective PKC- inhibitors: Advancement from LI to LO Anthony S. Prokopowicz III1, Charles L. Cywin1, Georg Dahmann2, Erick R. R. Young1, Ronald L. Magolda1, Mario G. Cardozo1, Derek A. Cogan1, Darren DiSalvo1, John D. Ginn1, Mohammed A. Kashem1, John P. Wolak1, Carol A. Homon1, Thomas M. Farrell1, Heather Grbic1, Hanbo Hu1, Paul V. Kaplita1, Lisa H. Liu1, Denice M. Spero1, Deborah D. Jeanfavre1, Kathy M. O'Shea1, Della M. White1, Joseph M. Woska Jr.1, and Maryanne L. Brown1. 1 ; Department of Research, Boehringer Ingelheim Pharmaceuticals, Inc, 900 Ridgebury Road, PO Box 368, Ridgefield, CT 06877-0368, 2 ; Department of Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss D-88397, Germany An uHTS campaign identified a series of 2, 4-diamino-5-nitropyrimidines as potent and selective PKC- inhibitors. Hit to lead data is presented showing that we were able to achieve.

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