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The threshold for activation is around 10 mV, and it shows voltage-dependent inactivation half-maximal voltage is around 68.5 mV ; . The decay time kinetics of the ensemble currents are 50 ms at the single-channel level 943 ; and 100 ms for the whole terminal current 943 ; . The mean open time during voltage pulses from a holding potential of 90 mV test potential of 10 mV 0.34 ms, and the closed time has two components with means of 1.78 and 86.6 ms. The activity NPo ; of the channel increases with voltage. In some of the patches, the channel did not inactivate and continued to be open throughout the test pulse. 3. NPT type In the presynaptic nerve terminals of the chick ciliary ganglion, one type of channel was characterized on a single-channel level, and two components were dissected on pharmacological and inactivation bases 990 ; . The single-channel conductance ranges between 11 and 14 pS with 110 mM Ba2 ; 818 ; and is reduced to 10 pS with 6 mM Ca2 and 6 mM Ba2 819 ; . The threshold for activation is around 30 mV, and it has little voltage-dependent inactivation. The activation rate constant in whole terminal current is 1.5 ms at positive potentials, and the deactivation rate at 80 mV 0.77 ms 824 ; . Although no inactivation was observed in the "whole cell" current when barium was the charge carrier, clear inactivation was detected when calcium ions replaced it, and the rate of inactivation increased with external calcium concentration 990 ; . This calcium-dependent inactivation may be applicable to other VDCC in nerve terminals that were examined with barium. 4. P like In the squid giant presynaptic terminal, the calcium current is probably carried via P channels 150 ; . The and zyprexa.
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